For instance, apart from the pathways highlighted in Figure 6, it would be interesting to determine whether the newly-identified receptor of GDF-15, namely GDNF-family receptor a-like (GFRAL) [70,71,72,73], mediates the GDF-15-induced rescue of the inhibitory effect of RSU-1 depletion on BC cell metastasis. Here, GFRAL is linked to breast cancer.