Albumin-stabilized paclitaxel nanocrystals showed enhanced uptake by SPARC+ B16F10 melanoma cells and in vivo anti-tumor efficacy [13], and albumin-stabilized hydroxycamptothecin nanocrystals showed enhanced intratumor accumulation and prolonged survival time in MCF-7 model tumor-bearing mice [14]. This evidence concerns the gene SPARC and neoplasm.