Inhibition or KO of the soluble epoxide hydrolase (sEH, inhibition of which elevates endogenous EET) protects MPTP-treated mice [157,158], and a double sEH and COX-2 inhibitor has protective effects on a rotenone-induced Drosophila melanogaster PD model [159]. The gene discussed is PTGS2; the disease is Parkinson disease.