SNCA and Parkinson disease: Conversely, PGL J2 treatment of SK-N-SH cells leads to the formation of aggregates containing ubiquitinated α-synuclein [146], and infusion into the SN of mice induces a pathology that mimics the slow-onset cellular and behavioral pathology of PD, including loss of DA neurons in the SN, α-synuclein aggregation, posture impairment, and microgliosis [115,147,148].