In humans, higher levels of PI 34:1 and no changes of PI 36:1, 36:2, 38:4, 38:5, 40:5, and 40:6, or no changes in total PI have been observed in parkin-mutant skin fibroblasts [280], and in the lipid rafts of frontal cortex from PD patients [33], respectively. Here, PRKN is linked to Parkinson disease.