Downregulation or pharmacological inhibition of CaMKKβ also decreases proliferation, migration and invasion of glioma [87], gastric [85,108] and liver cancer [86] cells and expression of a dominant negative CaMKK mutant suppresses medulloblastoma cell migration [109], suggesting that CaMKK activity is essential for this process. This evidence concerns the gene CAMKK2 and central nervous system cancer.