CaMKI controls the progression of MCF-7 breast cancer of cells through G1 [110], potentially by regulating cdk4 and retinoblastoma protein (Rb) phosphorylation, as overexpression of the kinase-inactive CaMKI K49A mutant prevents cdk4 activation and Rb hyperphosphorylation in WI-38 fibroblasts [17]. The gene discussed is CDK4; the disease is breast cancer.