NOS2 and pachyonychia congenita: Inducible nitric oxide synthase (iNOS) has been reported to influence malignant behaviors, including cell proliferation and invasion, by inducing the accumulation of mutations in p53, enrichment of basal-like gene signature, transactivation of the epidermal growth factor receptor, activation of NF-κB, and increased secretion of pro-inflammatory cytokines in malignancies, including PC [125,126].