With regard to the changes in S100A4 and E-cadherin expression following GTP administration, when TRAMP mice were supplied orally with 0.1% GTP solution three times a week for 24 weeks, tumor growth and progression were remarkably suppressed, which was associated with a reduction in S100A4 and restoration of E-cadherin in dorso-lateral prostate tissues [109]. Here, S100A4 is linked to neoplasm.