Clearance of myelin debris has been suggested to ameliorate disease via downregulation of transcription of pro-inflammatory factors like TNF, IL-1β, or inducible nitric oxide synthase (iNOS) and thus reducing IFNγ-mediated neuroinflammation in MS as well as EAE (Figure 1B) [204]. This evidence concerns the gene NOS2 and myeloid sarcoma.