eNOS dimer/monomer ratio was also decreased in diabetic db/db mice and normalized by saxagliptin [146], in erectile tissue of type 2 diabetes mellitus (T2DM) men [147], in mice with doxorubicin-induced cardiomyopathy and improvement by folic acid [148], in spontaneously hypertensive rats [149], and the improvement of eNOS coupling by increased eNOS dimer/monomer ratio by exercise training [150,151]. This evidence concerns the gene NOS3 and type 2 diabetes mellitus.