Activators and stimulators of the sGC represent a novel class of “repair” drugs of a (oxidatively) damaged sGC enzyme and they are intended to be used for the therapy of pulmonary hypertension and heart failure, but also in other indications, such as arterial hypertension, renal fibrosis/failure, liver cirrhosis, erectile dysfunction, atherosclerosis, restenosis, thrombosis, and inflammation [229]. This evidence concerns the gene SGCB and heart failure.