RAG1 and Hypertension: The contribution of B- and T-cells to the development of hypertension by angiotensin-II infusion was demonstrated by RAG-1−/− mice (recombination activating gene 1 deficient mice have no mature B and T lymphocytes) [49] and hypertension/vascular oxidative stress were also attenuated by genetic ablation of myelomonocytic cells [50].