The coagulation disorders observed in B. atrox snakebites patients can be explained by the presence of components of the venom with thrombin-like activity, which directly hydrolyze fibrinogen in fibrin [41,42,43] and pro-coagulants, which activate coagulation factors II and X [44,45], which results in the intravascular thrombin generation. Here, F2 is linked to blood coagulation disease.