Although the mechanisms responsible for allergies are not fully understood, induced PGE2 production offers some explanation [17,19,20] and our group hypothesize that anomalies in increased mRNA gene EP2 and IL-1RI expression are also involved because all IL-1β activity currently identified appears mediated through its only known functional receptor, IL-1RI [7,9]. This evidence concerns the gene IL1B and Allergy.