IGHE and asthma: These findings are in line with a study of 1,719 15-year-old participants in the German GINIplus birth cohort, which did not show any associations between sensitization and spirometric indices in children with asthma [41], but are in contrast to the American TENOR study of 1,261 children aged 6 to 17 years with severe or difficult-to-treat asthma, which showed an association between increased airflow limitation and higher IgE levels [42].