CYP11A1 and Adrenal insufficiency: Sixteen individuals from 12 different families were found to harbor the rs6161 variant in CYP11A1 (chr15:74635368C>T; c.940G>A), together with another very rare heterozygous variant (Table 2; families 1 to 10, 12, and 13), for an overall prevalence of CYP11A1 c.940G>A associated with PAI of unknown etiology of 20.8% (16 of 77) and a prevalence of 4.1% (16 of 395) in our cohorts of patients with adrenal insufficiency overall (Supplemental Table 2).