IL1B and heart disorder: The potential benefits of IL-1 blockade in patients with heart disease is further supported by the results of the phase III Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS) (47), in which patients with prior acute myocardial infarction were randomized to canakinumab, IL-1β blocker, or placebo, and showed a significant reduction in major adverse cardiac events.