The electrical disturbance at the basis of CPVT originates from “Ca2+ waves,” i.e., macroscopic surges of cytosolic Ca2+ resulting from spontaneous RyR opening at a point site, followed by auto-regenerative propagation (by Ca2+-induced Ca2+ release) of the ionic perturbation to the whole cell (82). This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.