Renewed interest in the link between serine biosynthesis and cancer has occurred within the last 10 years or so with the observation that an increased level of expression of PGDH has been found in human cancers such as breast (Possemato et al., 2011), cervical (Zhang et al., 2015), glioma (Liu et al., 2013), melanoma (Ou et al., 2015), colon (Yoon et al., 2015), pancreatic (Zhiwang et al., 2018), liver (Shanshan et al., 2017), kidney (Yoshino et al., 2017), and others as well. Here, PHGDH is linked to cancer.