In the same year, additional iPSC lines carrying different LMNA mutations leading to HGPS, atypical Werner Syndrome and dilated cardiomyopathy where also generated and showed that the reprogramming process blunts nuclear morphology abnormalities, no longer detectable in iPSCs, that are then re-acquired when iPSCs are differentiated into secondary fibroblasts (Ho et al., 2011). Here, LMNA is linked to dilated cardiomyopathy.