In the Hutchinson–Gilford Progeria Syndrome (HGPS), activation of a cryptic splice site within exon 11 of Lamin A by a silent gly-to-gly change at codon 608 (G608G; 150330.0022) leads to the production of an altered form of prelamin A, called progerin: this mutation induces the deletion of 50-amino acids in prelamin A that results in a loss of the endoproteolytic cleavage site; as a consequence, a farnesylated mutant prelamin A, progerin, is formed instead of mature Lamin A and accumulates inside the cells (Coutinho et al., 2009). Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.