In response to cancer-cell killing compounds, macrophages vigorously infiltrate the tumor and secrete tumorigenic factors, such as cathepsin (Shree et al., 2011; Alishekevitz et al., 2016), angiogenic factors (Alishekevitz et al., 2016) and chemokines (Welford et al., 2011), to promote tumor re-growth and metastasis. This evidence concerns the gene CTSS and neoplasm.