In the hypoxic tumor stroma, up-regulated HIF-1α and STAT1 expression in TAMs (Doedens et al., 2010) triggers NO secretion (Kusmartsev and Gabrilovich, 2005; Movahedi et al., 2010) and induces arginase activity respectively to induce T-cell apoptosis (Kusmartsev and Gabrilovich, 2005) and halt their expansion. Here, HIF1A is linked to neoplasm.