Colegio and colleagues further demonstrated that HIF-1α expression in tumor macrophages induce M2-associated genes such as VEGF, arginase 1 (Arg1), macrophage galactose-type lectin-1 (Mgl1) and macrophage galactose-type lectin-2 (Mgl2) in a colon carcinoma mouse model. The gene discussed is HIF1A; the disease is neoplasm.