Inactivation of the zebrafish ortholog of the HS chain modifier enzyme Hs3st2 significantly decreased tau hyperphosphorylation and tau-related neuropathology in vitro and in vivo in the Tg[HuC::hTauP301L/DsRed] zebrafish model of tauopathy (Sepulveda Diaz et al., 2015). This evidence concerns the gene MAPT and tauopathy.