MAPT and Alzheimer disease: Unlike amyloid-beta (Aβ) aggregates, which are specifically detected in AD patients, tau tangles are found in many neurodegenerative disorders such as corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), Pick’s disease, dementia pugilistica, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), and many others including AD (Alavi Naini and Soussi-Yanicostas, 2015).