However, on multivariate analysis including age, PSA level at diagnosis, biopsy Gleason score, clinical stage, and the modality of hormonal therapy, comorbidity with hypertension was not an independent prognostic factor of progression [HR (95% CI); 0.79 (0.47-1.31), p = 0.36] and any-cause death [HR (95% CI); 0.62 (0.33-1.17), p = 0.14], compared with absence of comorbidity with hypertension. The gene discussed is KLK3; the disease is hypertensive disorder.