In addition, administration of anti-PD-L1 antibody induced no further increase in cytotoxicity when combined with z-VRPR-fmk, suggesting that z-VRPR-fmk enhances Vγ9Vδ2 T lymphocyte cytotoxicity toward ABC-DLBCL cells mainly by inhibiting PD-L1 expression (Figure 2C). The gene discussed is CD274; the disease is diffuse large B-cell lymphoma.