To investigate whether ABC-DLBCL and GCB-DLBCL cells exert different immune-evasion effects on T lymphocytes, we expanded Vγ9Vδ2 T lymphocytes by culturing human peripheral blood mononuclear cells (PBMCs) from healthy adults and co-cultured them with three ABC-DLBCL cell lines (U2932, OCI-Ly3, and OCI-Ly10) and three GCB-DLBCL cell lines (BJAB, SUDHL-4, and SUDHL-6) in vitro. The gene discussed is CD8B; the disease is diffuse large B-cell lymphoma.