TNF and neoplasm: As shown in Figures 4A,B, compared with OMT or DDP alone treatment, co-treatment OMT with DDP significantly induced the increased intracellular IFN-γ and TNF-α and the decreased intracellular IL-2 in spleen lymphocytes, and the increased intracellular IFN-γ, TNF-α, and IL-2 in tumor infiltrating lymphocytes, suggesting that OMT and DDP synergistically enhance CD8+ T cells anti-tumor immune response.