Recent experiments from Morisada et al. in which primary tumor and abscopal tumor control rates were measured in a syngeneic mouse model of head and neck squamous cell carcinoma (SCC) following high-dose hypofractionated (8 Gy × 2) or low-dose daily fractionated (2 Gy × 10) RT in combination with concurrent anti-PD-1 showed that daily fractionated RT preserved peripheral and tumor-infiltrating CD8 T-cell accumulation and activation, reduced peripheral and tumor granulocytic myeloid derived suppressor cell (gMDSC) accumulation and did not impact Treg (40). Here, CD8A is linked to neoplasm.