ERBB2 and breast cancer: In a phase I study of a HER-2-based cancer vaccine combined with lapatinib in 12 patients with metastatic, trastuzumab-refractory, HER-2-overexpressing BC, the regimen was well tolerated and anti-HER-2-specific Ab was induced in all patients, while very satisfactory overall survival rates (1y-OS: 92%) have been observed (79).