CD274 and metastatic malignant neoplasm in the lymph nodes: Multivariate analysis showed lymph node metastasis, Treg count and PD-L1 expression on tumor cells were independent prognostic factors for OS, while TNM stage, Treg count and PD-L1 expression could be regarded as independent prognostic factors of DFS (all P < 0.05, Tables 5, 6).