HMGB1 and cancer: The number of CD3+ T cells in HMGB1 cytoplasmic expression group (339.39 ± 230.76) was more than that in group without HMGB1 cytoplasmic expression (233.30 ± 230.91, P < 0.05), suggesting that cytoplasmic expression of HMGB1 in cancer cells is associated with total T lymphocytes infiltrated in the tumor microenvironment.