Further analysis showed there was no significant difference in the number of CD8+ and FOXP3+ regulatory T cells between the two groups with or without HMGB1 cytoplasmic expression in tumor tissues [142.77 ± 118.29 vs. 104.70 ± 101.94, and 20(9.00, 53.75) vs. 18.00(6.00, 43.00)]. This evidence concerns the gene HMGB1 and neoplasm.