EGFR and head and neck squamous cell carcinoma: Furthermore, Bossi and coworkers reviewed in a recent article the prognostic and predictive value of EGFR in HNSCC (34), regarding HPV-positive patients they described different trials evaluating the combined effect of HPV status and EGFR expression on prognosis, showing that patients with EGFR-positive/HPV-negative cancer have the poorest outcomes, while the EGFR negative/HPV-positive group showed the best outcome in line with our results.