EGFR and head and neck squamous cell carcinoma: Association with HPV infection, EGFR expression level, and history of tobacco exposure are well-characterized prognosis factors in HNSCC: HPV-related transformation is associated with improved outcome (2); EGFR overexpression is associated with poor prognosis (10); and tobacco may contribute to increased EGFR expression through increased local hypoxia in tumor tissue (6).