In another study, in an attempt to characterize the mechanism of action of the neuregulin-non-competitive anti-HER3 therapeutic antibody 9F7-F11 that blocks the PI3K/AKT pathway and induces cell cycle arrest and apoptosis of breast cancer, it was found that 9F7-F11 activates JNK and consequently ITCH. The gene discussed is ITCH; the disease is breast carcinoma.