YAP1 and neoplasm: In relation to this, while different studies revealed that Hippo pathway activation or YAP/TAZ inactivation results in an anti-tumorigenic outcome, It was found that inactivation of the Hippo pathway (by LATS1/2 knockdown or YAP/TAZ overexpression) increases tumor immunogenecity and thus enhances its destruction by the immune system in vivo (69).