While knockdown of WWP1 increases the DeltaNp63α levels in the MCF10A and 184B5 immortalized breast epithelial cell lines and conferred resistance to doxorubicin-induced apoptosis, knockdown of WWP1 increases TAp63α level, induces apoptosis, and increases sensitivity to doxorubicin and cisplatin in the HCT116 colon cancer cell line (122). The gene discussed is WWP1; the disease is malignant colon neoplasm.