CDKN2A and cancer: Next to this global hypomethylation, MM is also characterized by the silencing of several cancer-related genes through hypermethylation, including but not limited to p73, p53, p15, p16, E-CAD, DAPK1, BNIP3, RB1, DIS3, CDKN2A, and CDKN2C (19).