Finally, next to the above described role of EZH2 in IMiD and PI resistance, it should be mentioned that Kikuchi et al. also described a correlation between phosphorylation-mediated inactivation of EZH2 and cell adhesion-mediated drug resistance (CAM-DR) against doxorubicin and the alkylating agent 4-OHCY in MM. Here, EZH2 is linked to Miyoshi myopathy.