To study the effects of combined expression of oncogenic ras and Jmjd6 in melanoma we generated triple transgenic fish, Et(kita:Gal4TA, UAS:mCherry)hmz1;Tg(UAS:eGFP-HRASV12)io006; Tg(UAS:eGFP-JMJD6)ka202 (designated as kita/Ras/Jmjd6, Figure 5E) and observe the fish for the development of melanoma at regular intervals, from 7 days to 1 month. The gene discussed is JMJD6; the disease is melanoma.