APC and cancer: Although no previous study reports the directly association between rs137854573 and HB, Rivera et al. (2011) has found that one FAP case with rs137854573 was diagnosed with osteoma, and another two cases of HB with two APC-truncating mutations (p.R1114X and p.Q1294X) had symptoms of FAP, suggesting that APC-truncating mutation carriers had a higher risk of comorbidity between FAP and cancers like osteoma and HB.