Among the genes affiliated with the 119 significant CpGs, SOCS3 and DOK2 were differentially expressed in the SAT of obesity patients, while seven genes (SOCS3, PRR5L, ABCG1, BRDT, B3GNT7, ZNF710, and RARRES1) were differentially expressed in the VAT of obesity patients. The gene discussed is DOK2; the disease is obesity due to melanocortin 4 receptor deficiency.