UGT1A1 and tuberculosis: First, the study is a single-center, small-sample study and the results should be validated in large-scale prospective studies; Second, this study only analyzed the two common variants in UGT1A1 gene, and other SNPs related to bilirubin levels were not included in the study, such as rs2417940 in SLCO1B3 gene, which reportedly explains only 0.64% of TB variation (Kang et al., 2010).