Doi et al. (2005) conducted an observational study for a mean of 9.0 years on 1,759 Japanese patients without diabetes. They observed that elevated CRP concentration is a significant predictor of diabetes, independent of obesity and insulin resistance. Analogous conclusions were also observed in American and European individuals (Freeman et al., 2002; Nakanishi et al., 2003). On the other hand, after adjusting for sex, adiposity, and insulin resistance, no association between CRP and the risk of T2DM was shown in other studies (Festa et al., 2002; Krakoff et al., 2003; Thorand et al., 2007). Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.