Deletions or SNPs in the gene locus of MACROD2 have been often associated with tumor progression, neurological and psychiatric disorders (Anney et al., 2010; Lionel et al., 2011; Perlis et al., 2012; Cheng et al., 2013; Jahanshad et al., 2013; Linnebacher et al., 2013; Tsang et al., 2013; Jones et al., 2014; Mohseni et al., 2014; Briffa et al., 2015; van den Broek et al., 2015; Hu et al., 2016; Sakthianandeswaren et al., 2018). The gene discussed is MACROD2; the disease is neoplasm.