In particular, four different SNPs mapping in STAT3 have been described as associated with MS in GWA studies: rs744166 (Jakkula et al., 2010), rs2293152 (Patsopoulos et al., 2011), rs9891119 (International Multiple Sclerosis Genetics Consortium [IMSGC] et al., 2011), and rs4796791 (International Multiple Sclerosis Genetics Consortium [IMSGC] et al., 2013). Here, STAT3 is linked to multiple sclerosis.