LLGL1 and cancer: Lgl protein regulates the apical-basal cell polarity in the epithelia (Grifoni et al., 2013); we previously demonstrated its functional conservation from Drosophila to humans (Grifoni et al., 2004), and we and others found the human orthologue HUGL-1 involved in cancers from different organs (Grifoni et al., 2004, 2007; Schimanski et al., 2005; Lu et al., 2009).