MYC and neoplasm: This deep organ alteration suggests a locally invasive, malignant behaviour of these mutant cells that may be favoured by clone confluence during growth, as it is with other tumour models in Drosophila (Menendez et al., 2010; Ballesteros-Arias et al., 2014), with MYC protein levels that appeared to increase along with phenotype severity (compare Figures 9A,B).