MAPT and Alzheimer disease: miR-26b-5p is dysregulated in the brain of sporadic AD patients and is known to be involved in Tau and apoptosis pathophysiological processes (Hébert et al., 2008; Hu et al., 2016), while miR-181-a-5p is involved in hippocampus-dependent memory formation (Zhang et al., 2017) and is also downregulated in CSF and brain of AD patients (Cogswell et al., 2008).