PSEN1 and Alzheimer disease: Aging is the main risk factor for AD which is also influenced by genetic factors such as the presence of full penetrant mutations in Amyloid precursor protein (APP), Presenilin 1 and 2 (PSEN1 and PSEN2) and Apolipoprotein E (APOE), sex (prevalence and incidence of AD are higher in women) and environmental and lifestyle factors (Jiang et al., 2013; Benayoun et al., 2015; Sohn et al., 2018).