We hypothesize that these gene expression changes are affecting processes related to neurodegeneration such as OS, inflammation, APP processing, Tau hyperphosphorylation, abnormal protein trafficking, cell cycle dysregulation, neurogenesis, Endoplasmic Reticulum (ER) stress, and behavioral changes among others, which may lead to SAMP8 senescent and AD-like phenotype. Here, MAPT is linked to Alzheimer disease.