MED12 and leiomyoma: Like other oncogenes, majority of MED12 mutations are located recurrently at the same amino acid position (codon 44), suggesting that glycine at codon 44 is mutation hotspot for leiomyomas and its location in evolutionarily conserved nucleotide sequences makes it a putative causal variant (Matam et al., 2015; Wang et al., 2015, 2017).