However, In leiomyomas, somatic mutations (be it missense, frameshifts, or Indels) in MED12, particularly in exon-2 region, are proposed to be one of the underlying cause of tumorigenesis (McGuire et al., 2012; Ravegnini et al., 2013; Halder et al., 2014; Kämpjärvi et al., 2016a; Sadeghi et al., 2016). This evidence concerns the gene MED12 and leiomyoma.