Another new function of IL-33 discovered from non-basophilic leukemia, a rare subtype of acute myeloblastic leukemia, indicated IL-33 enhanced the basophilic differentiation of MYB-GATA1 expression, demonstrating a new role of IL-33 in leukemic cells and CD34-positive primary cells (29). The gene discussed is IL33; the disease is acute basophilic leukemia.