In cord blood transplant modality, HLA-DPB1 mismatch was also associated with a significant reduction of leukemia relapse (HR 0.61, P = 0.001), and no significant effect of HLA-DPB1 mismatch was observed on the risk of acute GVHD, engraftment or mortality (111). This evidence concerns the gene HLA-DPB1 and acute graft versus host disease.