Currently reported data in the literatures suggest that Tregs might be the most important regulatory cells in preventing GVHD (4) through a series of approaches, including aurora A/JAK2 inhibition (91, 92), selective TNFR2 activation (93), DR3 signaling modulation (94), activated protein C signals (95), and IL-2 (96), which can be used to alleviate GVHD through a Tregs-dependent mechanism. The gene discussed is TNFRSF1B; the disease is graft versus host disease.