CSF3 and graft versus host disease: Based on immune tolerance induced by G-CSF, such as the ability to polarize T cells from the Th1 to the Th2 phenotype and the hyporesponsiveness of T cells, Huang's group established a modified DLI protocol (127) that includes the following: (i) the use of G-CSF mobilized peripheral blood stem cell harvests (G-PBSCs) instead of a steady lymphocyte infusion; (ii) the introduction of short-term immune suppressive agents, including cyclosporine A (CSA) or methotrexate (MTX), to further decrease the incidence of GVHD.