Consistent with the observations of the latter study (81), daily treatment of P. berghei ANKA-infected mice with recombinant IFN-α, which to a certain extent resembles a situation of high levels of type I IFN production at early stage of infection, also significantly increased IFN-γ production by splenic CD8+ T cells, markedly reducing parasitemia and preventing cerebral malaria (177). This evidence concerns the gene IFNG and parasitic infectious disease.