Palomo et al. found that, compared to infected WT mice, P. berghei ANKA-infected mice deficient in IFNαR had similar parasitemia, reduced expression of IFN-γ and granzyme B by T cells, decreased expression of T cell-attracting chemokine CXCL9, and low infiltration of CXCR3+-expressing CD8 T cells to the brain. The gene discussed is IFNG; the disease is parasitic infectious disease.