Neutrophils from individuals with cerebral malaria have reduced chemotaxis to Interleukin 8 (IL8) and N-formyl-l-methionyl-l-leucyl-phenylalanine (fMLP) (14), and this reduction in chemotaxis may be partly due to increased free heme (14, 18) and/or decreased neutrophil expression of IL8 receptor CXCR2 (as reported in P. vivax malaria) (14, 30). The gene discussed is CXCL8; the disease is cerebral malaria.