GPT and diabetic kidney disease: Mice fed a HFD also showed significant increases in (i) total body weight secondary to an increase in fat mass, but not lean mass; (ii) an increase in the serum levels of alanine aminotransferase (ALT) indicating the development of liver injury; (iii) increase in urine albumin to creatinine ratio (ACR) as well as a (iv) a decrease in creatinine clearance (CrCl) indicating the development of diabetic nephropathy (proteinuria) and glomerular dysfunction (P < 0.05).