CD6 and demyelinating disease: In the collagen-induced arthritis (CIA) model, Cd6 knockout mice were characterized by earlier disease onset and increased clinical score as well as worsened hallmarks for the disease, namely IL-6 and TNF expression in the joints (63), whereas in a model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), the absence of CD6 confers resistance to the demyelinating disorder (61).