CD6 and multiple sclerosis: The hypothesis that the lower EAE scores in the absence of CD6 are due to less transmigration is, however, in apparent contradiction with the interpretation that is given for the CD6-dependent corresponding human pathology: CD6 is a susceptibility gene for multiple sclerosis (68), and individuals carrying a disease-related polymorphism at the locus rs17828933 within the first intron have increased levels of CD6Δd3 (69), a naturally occurring CD6 isoform that lacks the CD166-binding domain (70).