IL-2 is believed to regulate the expression of Bcl-6 through activation of Akt, which serves to control the activity of Foxo family transcription factors (89), Activation of Akt also alters the expression of proteins involved in CD8 T cell trafficking such as CD62L, CCR7, and S1P1, so as to promote their migration to peripheral sites of infection and inflammation (90–92). The gene discussed is AKT1; the disease is infection.