Based on previous findings demonstrating an intestinal epithelial barrier dysfunction in IBD, with up- (CDN1, DSG3) or downregulation (CLDN8, OCLDN, MEP1A, and MAGI1) of particular genes in active IBD compared to healthy individuals (23), we studied the correlation between IL13RA2 expression and these barrier genes. Here, CLDN8 is linked to inflammatory bowel disease.