Nevertheless, a study of TLR8−/− mice indicated that TLR8 regulates TLR7 expression and protects mice from autoimmunity, since TLR8−/− mice, but not TLR8−/− TLR7−/− mice, developed features of lupus-like syndrome (15). This evidence concerns the gene TLR7 and drug-induced lupus erythematosus.