Moreover, Eomes was co-expressed with Programmed Death-1 (PD-1, encoded by Pdcd1) and T-cell immunoglobulin and mucin-domain containing-3 (Tim-3, encoded by Havcr2) in CD8+ TILs by day 12 to day 25 of tumor challenge. The gene discussed is PDCD1; the disease is neoplasm.