TNF and neoplasm: Deficiency of Eomes in T cells also dampened effector cytokine (IFN-γ and TNF-α) production and cytotoxicity (marked by surface CD107a expression and Granzyme B production) of CD8+ T cells in the tumor (Figures 2C,D), although effector functions of CD8+ T cells in spleen and TDLN was not affected (Figure S1C).