Previous studies have defined the role of soluble mediators, such as the chemokine C-C motif chemokine ligand 2/monocyte chemoattractant protein 1 (CCL2/MCP1) and the receptors C-C motif chemokine receptor (CCR) 2 and 5 in NASH (10). Here, CCL2 is linked to metabolic dysfunction-associated steatohepatitis.