CASP1 and AIDS: • Overlapping clinical features with AIDs • Increased expression of genes related to the NLRP3 inflammasome, IL-1a and IL-1b, and caspase 1 in blood • IL-1β and IL-1α implicated in myocarditis and aneurysm formation in LCWE -induced mouse model of KD • Efficacy of IL-1 blockade