Presence of IgM aPS/PT was detected 65.8% in the group of APS, 16.7% in the group of SNAPS, 81.8% in the group of asymptomatic APA carriers, 5.3% in the group of thrombosis/ obstetric, and 6.7% in HD. Here, CD40LG is linked to autoimmune polyendocrinopathy.