CD40LG and autoimmune polyendocrinopathy: The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thrombotic and/or obstetrical manifestations associated with the persistent positivity for at least one of three markers: lupus anticoagulant (LA), anti-cardiolipin antibodies (aCL) or anti-beta2-glycoprotein I (aβ2GP1) antibodies of either IgG or IgM isotype (1, 2).