TNFRSF8 and Hodgkins lymphoma: Analysis of TRAF1 in Hodgkin–Reed–Sternberg cells of highly proliferating tumors such as Hodgkin lymphoma (HL) and anaplastic large cell lymphoma led to the suggestion that TRAF1 contributes to apoptosis resistance downstream of CD30, and therefore plays an important role in the pathogenesis of classical HL (50).